Changes in tryptase levels during cardiac surgery in patients at low risk for allergic reactions

Tryptase test can be used as a clinical marker of mast cell activation. The present study is was aimed to identify variations in serum tryptase levels and their possible relationships with allergic reactions protamine low-risk patients undergoing cardiac bypass surgery. Thirty according American Society Anesthesiologists physical status III who underwent surgery were enrolled. This prospective, non-randomised, conducted an operating room. Venous blood samples for measurements obtained from upon admission the room immediately before 30 min after initiation administration. Signs recorded management steps based on rapid effect response-based assessments diagnosis treatment decisions during administrations described. Serum signs reactions, primarily mean arterial pressure (MAP), recorded. increased significantly progressively procedure (study power, 80%; sample size, 28; power analysis, 99.8% α=0.05); however, did not reach sufficiently high level confirm reaction. MAP heart rate decreased 50% patients. Although when compared baseline levels, protamine-associated increases significant failed provide unequivocal indication response protamine.